Medicube Salmon DNA PDRN Pink Hyaluronic Moisturizing Cream 50ml

K-Beauty's most talked-about ingredient, now in your moisturiser. The Medicube Salmon DNA PDRN Pink Hyaluronic Cream is a next-generation Korean moisturiser that combines 5,000ppm of Salmon DNA PDRN with a powerhouse stack of 10 types of Hyaluronic Acid, ceramides, peptides, and Niacinamide — all in one lightweight, non-greasy texture that absorbs easily and leaves a silky, comforted finish with no sticky residue.

PDRN (Polydeoxyribonucleotide) is a highly purified DNA fragment derived from salmon, originally developed for clinical wound healing. It activates fibroblasts to stimulate collagen, elastin, and hyaluronic acid synthesis, increases microcirculation, and reduces inflammatory activity  — bringing the regenerative power of in-clinic treatments into your daily skincare routine.

Why it works:

• 5,000ppm Salmon DNA PDRN — promotes tissue repair, stimulates collagen production, and supports skin regeneration at a cellular level, making it effective for signs of ageing, uneven texture, and post-breakout recovery 
• 10 types of Hyaluronic Acid — penetrate the dermis at multiple molecular weights, boosting elasticity and moisture retention at every layer of the skin 
• Niacinamide 2% — fades stubborn blemishes and brightens uneven skin tone  for a noticeably clearer, more even complexion
• 5 ceramides + Cholesterol + Phytosphingosine — a complete barrier-repair complex that locks in moisture and shields skin from environmental stressors
• Peptide complex (Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4) — cell-communicating ingredients that signal the skin to produce more collagen and improve elasticity 
• Adenosine — clinically proven to reduce fine lines and wrinkles by promoting skin firmness
• Centella Asiatica & Panthenol — calm redness, soothe irritation, and support barrier healing
• Meadowfoam Seed Oil & Rosa Damascena Extract — nourish and condition for a lasting soft-skin finish
• Free from harsh alcohols, common allergens, parabens, and sulfates  — suitable for sensitive skin

Clinical results: 0.4% improvement in blemish tone and 14.25% improvement in blemish and discolouration area after consistent use . After 4 weeks, skin appears visibly firmer, more toned, and younger-looking with diminished fine lines and wrinkles. 

How to use: As the final step of your morning and evening skincare routine, apply a moderate amount to the face. Smooth outward from the centre and pat gently with fingertips until fully absorbed. For best results, pair with the full Medicube PDRN Pink routine — toner, serum, and mask.

Suitable for: All skin types · Ageing & mature skin · Blemish-prone & post-acne skin · Sensitive & reactive skin · Fragrance-present formula · Made in Korea 🇰🇷

Why Seoulma recommends it:

PDRN is the ingredient that moved from dermatology clinics to K-Beauty shelves, and Medicube has built one of the most well-formulated versions of it available for home use. What makes the Pink Hyaluronic Cream stand out even within the crowded PDRN category is how much it packs into a single moisturiser — this isn't just a PDRN delivery vehicle, it's a genuinely complete daily cream.

The 10-layer Hyaluronic Acid system alone is remarkable. Most moisturisers use one or two forms of HA — this one uses ten, each at a different molecular weight, to ensure hydration reaches every depth of the skin rather than just sitting on the surface. Stack that with a full ceramide complex, a multi-peptide blend, and Niacinamide for brightening, and you have a moisturiser that replaces three or four separate steps in one jar.

We especially recommend it for anyone dealing with the aftermath of breakouts — post-acne marks, uneven tone, skin that feels weakened or sensitised. The PDRN accelerates recovery, the ceramides rebuild the barrier, and the Niacinamide fades the marks left behind. It's one of the most complete blemish-recovery moisturisers we carry. And the texture is genuinely a joy — lightweight and fast-absorbing, with a subtle healthy glow finish that works beautifully under SPF or makeup.